虾青素增加（视网膜）之脉络膜血流速度

作者：

斋藤M，吉田K，齐藤，富士屋一个，Ohgami K，Kitaichi ñ，冢原石田小号，小号大野。

来源

眼科部，西7丁目，北15柔，北区，札幌060-8638，日本北海道大学研究生院医学研究。

摘要目的：

此前曾有研究表明，虾青素（AXT）具有抗氧化和抗炎作用，除了它能够缩短血液运输时间。由于激光散斑流量图（LSFG）可以无创性侦测脉络膜循环的血流动力学，我们使用这项技术来评估是否连续摄入艾诗特（虾青素）12毫克/天，能否增加定量血流速度。

方法：

在这项随机，双盲，安慰剂对照研究中，我们研究了20名健康志愿者超过4周期间摄入12毫克的艾诗特（AXT）或安慰剂胶囊。LSFG测量前摄入右眼的所有科目，并在艾诗特（AXT）治疗2和4周后。用LSFG值来计算平方模糊率（SBR），这是一个相对血流速度的定量指标。

结果：

视网膜黄斑的SBR值在摄入艾诗特（AXT）4周后显著增加，与摄取前值（Wilcoxon符号秩检验，P = 0.018）。与此相反，服用安慰剂的对照组视网膜黄斑的SBR值没有统计学差异（弗里德曼检验，P = 0.598）。服用艾诗特（AXT）12mg/天组未发现任何主观或客观的不良事件。

结论：

结果显示，超过4周期间的艾诗特（AXT）的治疗可以提高脉络膜血流速度无任何不良影响。

Astaxanthin increases choroidal blood flow velocity.

Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S.

Source

Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi-7-chome, Kita 15-jou, Kita-ku, Sapporo, 060-8638, Japan.

Abstract

PURPOSE:

Previous studies have reported that astaxanthin (AXT) has antioxidative and anti-inflammatory effects in addition to its ability to shorten blood transit times. As laser speckle flowgraphy (LSFG) can noninvasively visualize the hemodynamics of the choroidal circulation, we used the technique to evaluate whether continuous ingestion of 12 mg of AXT per day could increase quantitative blood flow velocity.

METHODS:

In this randomized, double-blind, placebo-controlled study, we examined 20 healthy volunteers who ingested 12 mg AXT or placebo capsules over a 4-week period. LSFG was measured in the right eyes of all subjects at pre-ingestion, and at 2 and 4 weeks after the treatment of AXT. LSFG values were used to calculate the square blur rate (SBR), which is a quantitative index of relative blood flow velocity.

RESULTS:

A significant increase of the macular SBR was seen 4 weeks after AXT ingestion when compared to the pre-ingestion values (Wilcoxon signed-rank test, P = 0.018). In contrast, no statistical difference in the macular SBR was detected in the placebo group (Friedman test, P = 0.598). No subjective or objective adverse events were found after the 12-mg AXT ingestion.

CONCLUSIONS:

Results suggest that administration of AXT over a 4-week period can elevate the choroidal blood flow velocity without any adverse effects.